Disease-related response to inhaled nitric oxide in newborns with severe hypoxaemic respiratory failure

@article{Mercier1998DiseaserelatedRT,
  title={Disease-related response to inhaled nitric oxide in newborns with severe hypoxaemic respiratory failure},
  author={J. Mercier and T. Lacaze and L. Storme and J M Roze and Anh Tuan Dinh-Xuan and Michel Dehan},
  journal={European Journal of Pediatrics},
  year={1998},
  volume={157},
  pages={747-752}
}
Inhaled nitric oxide (iNO) has been shown to improve oxygenation in severe persistent pulmonary hypertension of the newborn (PPHN). However, PPHN is often associated with various lung diseases. Thus, response to iNO may depend upon the aetiology of neonatal acute respiratory failure. A total of 150 (29 preterm and 121 term) newborns with PPHN were prospectively enrolled on the basis of oxygenation index (OI) higher than 30 and 40, respectively. NO dosage was stepwise increased (10–80 ppm… CONTINUE READING

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