Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.

@article{Orso2005DiseaserelatedPI,
  title={Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.},
  author={Giuseppe Orso and Andrea Martinuzzi and Maria Giovanna Rossetto and Elena Sartori and Mel B. Feany and Andrea Daga},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 11},
  pages={
          3026-34
        }
}
Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative diseases characterized by progressive weakness and spasticity of the lower limbs. Dominant mutations in the human SPG4 gene, encoding spastin, are responsible for the most frequent form of HSP. Spastin is an ATPase that binds microtubules and localizes to the spindle pole and distal axon in mammalian cell lines. Furthermore, its Drosophila homolog, Drosophila spastin (Dspastin), has been recently shown to regulate… CONTINUE READING
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