Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment

@article{Schram2020DiseasePI,
  title={Disease propagation in amyotrophic lateral sclerosis (ALS): an interplay between genetics and environment},
  author={Sarah Schram and J. Loeb and Fei Song},
  journal={Journal of Neuroinflammation},
  year={2020},
  volume={17}
}
  • Sarah Schram, J. Loeb, Fei Song
  • Published 2020
  • Biology, Medicine
  • Journal of Neuroinflammation
  • Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease affecting the neuromuscular system. While there have been a number of important genetic discoveries, there are no therapeutics capable of stopping its insidious progression. Lessons from clinical histories reveal that ALS can start focally at a single limb, but then segmentally spread up and down the spinal cord as well as in the motor cortex and cortex of frontal and temporal lobes until respiratory muscles fail. With or… CONTINUE READING

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