Disease progression and survival following specific AIDS‐defining conditions: a retrospective cohort study of 2048 HIV‐infected persons in London

  title={Disease progression and survival following specific AIDS‐defining conditions: a retrospective cohort study of 2048 HIV‐infected persons in London},
  author={Ann Petruckevitch and Julia del Amo and Andrew N Phillips and Anne M Johnson and Judith Stephenson and Noreen Desmond and Thomas Hanscheid and Nicola Low and Anthony Newell and Angela I N Obasi and Katie Paine and Alexander S. Pym and Cecilia Theodore and Kevin M. de Cock},
Objective: To assess the impact of specific AIDS‐defining conditions on survival in HIV‐infected persons, with emphasis on the effect of tuberculosis. Methods: A retrospective cohort analysis of HIV‐infected Africans and non‐Africans attending 11 specialist HIV/AIDS units in London enrolled for a comparison of the natural history of HIV/AIDS in different ethnic groups. Results: A total of 2048 patients were studied of whom 627 (31%) developed 1306 different AIDS indicator diseases. Pneumocystis… 

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Effect of tuberculosis on the survival of women infected with human immunodeficiency virus.

Although results were imprecise because few women incurred TB, irrespective of HAART exposure, incident TB increases the hazard of AIDS-related death among HIV-infected women.

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This study demonstrated the positive impact of HAART in the survival of Cuban AIDS patients with TB and also identified advanced immunodepression and opportunistic infections as predictors of mortality.

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Person with AIDS and EPTB had a more complicated medical course with lower CD4 counts at time of AIDS diagnosis and more OIs over the follow-up period than persons withAIDS and PTB, however the survival profiles for the two groups were comparable.

Survival by AIDS defining condition in rural Uganda

The survival for most AIDS defining conditions was generally shorter and the median CD4 lymphocyte count higher than studies reported from developed countries, however, the conditions with the longest survival had a similar survival to that in developed countries and these conditions have a high background level in this population.

Long-term effect of preventive therapy for tuberculosis in a cohort of HIV-infected Zambian adults

Both PT regimens protect against tuberculosis for at least 2.5 years but appear to have no effect on HIV progression or mortality.

Natural history of human immunodeficiency virus disease in southern India.

In a retrospective analysis of patients receiving care at YRG Center for AIDS Research and Education, a tertiary HIV referral center in southern India, the mean duration of survival from serodiagnosis was 92 months and patients who had > or =1 opportunistic infection were two times more likely to die.

Changes in acquired immunodeficiency syndrome-related lymphoma since the introduction of highly active antiretroviral therapy.

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Differences in progression to AIDS and death and CD4+ lymphocyte decline between HIV-1-infected Africans and non-Africans in London could not be attributed to ethnicity or different viral subtypes and were the major determinants of outcome.

Does the onset of tuberculosis in AIDS predict shorter survival? Results of a cohort study in 17 European countries over 13 years

The onset of tuberculosis in patients with AIDS predicts a substantial increase in mortality, and if the association is causal preventive chemotherapy and aggressive treatment of tuberculosis could improve survival in AIDS.

Spectrum of disease in Africans with AIDS in London

HIV‐infected African patients presented at lower levels of CD4+ lymphocyte count, at a more advanced clinical stage, and with different AIDS‐indicator diseases as compared with non‐Africans, suggesting better survival chances in the UK.

Accelerated course of human immunodeficiency virus infection after tuberculosis.

Although active tuberculosis may be an independent marker of advanced immunosuppression in HIV-infected patients, it may also act as a cofactor to accelerate the clinical course of HIV infection.

Factors affecting survival in patients with the acquired immunodeficiency syndrome.

A recently proposed staging system for patients with AIDS, based on a score that takes account of the CD4 count and the number and type of AIDS-defining illnesses, has been validated in two cohorts of patients.

Staging system for clinical AIDS patients

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The decrease in CD4 lymphocyte count at AIDS diagnosis indicates that patients are being diagnosed as having AIDS at ever more advanced stages of immunodeficiency.

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Survival differences in patients with AIDS.

Within a setting of comparable clinical care, survival from the point of diagnosis of AIDS is associated most strongly with the initial AIDS diagnosis, but differences in age, gender, race, and risk behavior also exert an influence on survival.