Disease prevention—should we target obesity or sedentary lifestyle?

@article{Charansonney2010DiseasePW,
  title={Disease prevention—should we target obesity or sedentary lifestyle?},
  author={O. Charansonney and J. Despr{\'e}s},
  journal={Nature Reviews Cardiology},
  year={2010},
  volume={7},
  pages={468-472}
}
Obesity is a major health challenge facing the modern world. Some evidence points to obesity itself as the main driver of premature mortality. We propose that this view is oversimplified. For example, high levels of physical activity and cardiorespiratory fitness are associated with lower mortality, even in those who are overweight or obese. To address this issue, we combine epidemiological and physiological evidence in a new paradigm that integrates excess calorie intake, sedentary behavior… Expand
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Authors' reply: Disease prevention and sedentary lifestyle
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The model showed that for any given level of physical activity, sedentary time had detrimental effects on cardiometabolic health, and that public health guidelines on physical activity fail to consider sedentary lifestyle, therefore, meeting current physical activity guidelines does not necessarily prevent the deleterious metabolic consequences of sedentary lifestyles. Expand
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This paper puts forward an innovative model providing a framework for understanding some of the physio logical consequences of sedentary behavior, and argues that the model must be considered in a broader context, taking into account how sedentarybehavior can coexist with high levels of both physical activity and cardio‐ respiratory fitness. Expand
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Overweight and obese men and women, who are at increased risk for CVD and T2D due to sedentary lifestyle, poor diet, and excess body weight, should be encouraged to become more physically active and consume more nutrient-dense foods, even if the healthier lifestyle does not produce desired weight loss. Expand
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  • 2015
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These results suggest that a very large exercise prescription reduces the probability of an individual being in positive energy balance, despite what can be considered by any standard as consuming a tremendously large amount of energy. Expand
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An integrated patient-centric model combining physiology with epidemiological evidence to characterize the individual risk attached to PA level, PF, and SB is developed and can improve the individualized prescription of PA modalities. Expand
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Overweight/obese men and women who are at increased risk for cardiovascular disease and type 2 diabetes as a result of sedentary lifestyle, poor diet, and excess body weight should be encouraged to engage in regular physical activity and improve their diet, regardless of whether the healthier lifestyle leads to weight loss. Expand
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There is a need for dose‐response evidence, and for a broader understanding of the underlying mechanisms by which prolonged sitting time may affect cancer survivors' health, to help extend disease‐free survival and enhance quality of life. Expand
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MVPA is a strong predictor of cardiometabolic health among adults, independent of time spent in SB, and among women, greater SB and less lifestyle moderate activity and MVPA were each independently associated with the metabolically abnormal phenotype, whereas only less MVPA was associated with it in men. Expand
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It is demonstrated that the moderate exercise training protocol improves the sleep profile in older people, but the metabolism adaptation does not persist, suggesting that this population requires training strategy modifications as to ensure consistent alterations regarding metabolism. Expand
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Time in MVPA and accumulating ST in shorter sedentary bouts is inversely related to adiposity, and these associations may be mediated by CRF, which should be given to programs that target increases in MV PA, which may influence CRF while reducing sedentary recreational behaviors. Expand
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