Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma: a pilot study.

@article{Fukuda2001DiseaseOM,
  title={Disease outcome may be predicted by molecular detection of minimal residual disease in bone marrow in advanced neuroblastoma: a pilot study.},
  author={Miho Fukuda and Yoshimi Miyajima and Yoshihiro Miyashita and Keizo Horibe},
  journal={Journal of pediatric hematology/oncology},
  year={2001},
  volume={23 1},
  pages={10-3}
}
PURPOSE This pilot study focussed on whether sequential molecular detection of minimal residual disease (MRD) in bone marrow (BM) could predict the outcome of patients with advanced neuroblastoma. PATIENTS AND METHODS Bone marrow samples from 21 patients older than age 12 months with stage IV neuroblastoma were sequentially examined for tumor cell contamination by detecting tyrosine hydroxylase (TH) messenger ribonucleic acid (mRNA) using reverse transcription-polymerase chain reaction (RT… CONTINUE READING