Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.

Abstract

Ryanodine Receptors (RyRs) are huge Ca²⁺ release channels in the endoplasmic reticulum membrane and form targets for phosphorylation and disease mutations. We present crystal structures of a domain in three RyR isoforms, containing the Ser2843 (RyR1) and Ser2808/Ser2814 (RyR2) phosphorylation sites. The RyR1 domain is the target for 11 disease mutations… (More)
DOI: 10.1016/j.str.2012.04.015

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Cite this paper

@article{Yuchi2012DiseaseMI, title={Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.}, author={Zhiguang Yuchi and Kelvin K.W. Lau and Filip Van Petegem}, journal={Structure}, year={2012}, volume={20 7}, pages={1201-11} }