Disease-modifying effects of metabolic perturbations in ALS/FTLD

@inproceedings{Jawaid2018DiseasemodifyingEO,
  title={Disease-modifying effects of metabolic perturbations in ALS/FTLD},
  author={Ali Jawaid and Romesa Khan and Magdalini Polymenidou and Paul E. Schulz},
  booktitle={Molecular neurodegeneration},
  year={2018}
}
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two fatal neurodegenerative disorders with considerable clinical, pathological and genetic overlap. Both disorders are characterized by the accumulation of pathological protein aggregates that contain a number of proteins, most notably TAR DNA binding protein 43 kDa (TDP-43). Surprisingly, recent clinical studies suggest that dyslipidemia, high body mass index, and type 2 diabetes mellitus are associated with… CONTINUE READING
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