Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

@article{Kazim2014DiseaseME,
  title={Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease},
  author={Syed Faraz Kazim and Julie Blanchard and Chun-Ling Dai and Yunn-Chyn Tung and Khalid Iqbal},
  journal={Neurobiology of Disease},
  year={2014},
  volume={71},
  pages={110-130}
}
Besides the presence of amyloid beta (Aβ) plaques and neurofibrillary tangles, neurogenesis and synaptic plasticity are markedly impaired in Alzheimer's disease (AD) possibly contributing to cognitive impairment. In this context, neurotrophic factors serve as a promising therapeutic approach via utilization of regenerative capacity of brain to shift the balance from neurodegeneration to neural regeneration. However, besides more conventional "bystander" effect, to what extent can neurotrophic… CONTINUE READING
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