Disease model: familial adenomatous polyposis.

  title={Disease model: familial adenomatous polyposis.},
  author={Riccardo Fodde and Ron Smits},
  journal={Trends in molecular medicine},
  volume={7 8},
Mutations in the APC gene are responsible for familial adenomatous polyposis (FAP) and for the majority of sporadic colorectal cancers. The establishment of genotype-phenotype correlations in FAP is often complicated by the great clinical variability observed among carriers of the same APC mutation even within the same kindred. This variability is likely to arise from the interaction of genetic and environmental modifying factors, the dissection of which ideally requires the employment of mouse… CONTINUE READING

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