Disease mechanism: Unravelling Wiskott–Aldrich syndrome

@article{Kirchhausen1996DiseaseMU,
  title={Disease mechanism: Unravelling Wiskott–Aldrich syndrome},
  author={Tomas Kirchhausen and Fred S. Rosen},
  journal={Current Biology},
  year={1996},
  volume={6},
  pages={676-678}
}
The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease. 
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