Disease course heterogeneity and OCT in multiple sclerosis

@article{Balk2014DiseaseCH,
  title={Disease course heterogeneity and OCT in multiple sclerosis},
  author={L. J. Balk and Prejaas Tewarie and Joep Killestein and Chris H. Polman and B. M. J. Uitdehaag and Axel Petzold},
  journal={Multiple Sclerosis Journal},
  year={2014},
  volume={20},
  pages={1198 - 1206}
}
Background: The heterogeneity of the disease course in multiple sclerosis (MS) remains a challenge for patient management and clinical trials. Objective: The objective of this paper is to investigate the relationship between disease course heterogeneity and retinal layer thicknesses in MS. Methods: A total of 230 MS patients and 63 healthy control subjects were included. Spectral-domain OCT scanning of the peripapillary and macular regions was performed, followed by automated eight-layer… 
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TLDR
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TLDR
In patients with MS, at less advanced disease stages, RLT was especially associated with cognitive flexibility promoting OCT as a potential marker advocating further extensive neuropsychological examination.
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TLDR
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TLDR
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TLDR
GCL thinning occurs in MS both with and without prior ON, and may be associated with visual function and EDSS score, which suggests that the GCL is a promising biomarker, which may be used to examine in vivo neurodegeneration in ON and MS.
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References

SHOWING 1-10 OF 36 REFERENCES
Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
TLDR
Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings, carving out distinct patterns in different MS subtypes.
Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning
TLDR
The findings suggest that retinal changes in MS reflect global CNS processes, and that OCT-derived GCIP thickness measures may have utility as an outcome measure for assessing neuroprotective agents, particularly in early, active MS.
Retinal Axonal Loss Begins Early in the Course of Multiple Sclerosis and Is Similar between Progressive Phenotypes
TLDR
Retinal axonal loss is increasingly prominent in more advanced stages of disease – progressive MS>RRMS>CIS – with proportionally greater thinning in eyes previously affected by clinically evident optic neuritis.
An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography.
TLDR
There are significant global reductions in RNFLT and macular volume in the eyes of secondary progressive sclerosis patients not previously affected by ON, but not in primary progressive MS patients, compared with controls, which may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve.
Optical coherence tomography and disease subtype in multiple sclerosis
TLDR
Retinal nerve fiber layer (RNFL) thickness is significantly decreased in multiple sclerosis (MS) optic neuritis (ON) eyes, unaffected fellow eyes of patients with MS ON, and MS eyes not affected by ON in the authors' cohort.
Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes
TLDR
This first large study in untreated patients with multiple sclerosis with different disease subtypes shows that brain atrophy proceeds relentlessly throughout the course of MS, with a rate that seems largely independent of the MS subtype, when adjusting for baseline brain volume.
Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis
Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography
TLDR
The findings indicate a primary retinal pathology involving the inner nuclear layer in primary progressive MS, and suggest possible subclinical episodes of optic neuritis or retrograde trans-synaptic degeneration of retinal ganglion cells and their axons.
Differences in retinal nerve fiber layer atrophy between multiple sclerosis subtypes
Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype.
TLDR
The rate of development of brain atrophy is largely independent of the course of the disease and other clinical characteristics, thereby stressing the need for early neuroprotective treatment in MS.
...
...