Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages.

@article{Deriy2009DiseasecausingMI,
  title={Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages.},
  author={Ludmila V. Deriy and Erwin A. Gomez and Guangping Zhang and Daniel W Beacham and Jessika A Hopson and Alexander J. Gallan and Pavel D. Shevchenko and Vytautas P. Bindokas and Deborah J. Nelson},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 51},
  pages={
          35926-38
        }
}
Alveolar macrophages (AMs) play a major role in host defense against microbial infections in the lung. To perform this function, these cells must ingest and destroy pathogens, generally in phagosomes, as well as secrete a number of products that signal other immune cells to respond. Recently, we demonstrated that murine alveolar macrophages employ the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel as a determinant in lysosomal acidification (Di, A., Brown, M. E., Deriy… CONTINUE READING

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