Disease burden at the progenitor level is a feature of primary myelofibrosis: a multivariable analysis of 164 JAK2 V617F-positive myeloproliferative neoplasm patients.

@article{Galiatsatos2011DiseaseBA,
  title={Disease burden at the progenitor level is a feature of primary myelofibrosis: a multivariable analysis of 164 JAK2 V617F-positive myeloproliferative neoplasm patients.},
  author={Polymnia Galiatsatos and Donna M. Williams and Ophelia C. Rogers and Mary Ann Isaacs and Jerry L. Spivak and Alison R Moliterno},
  journal={Experimental hematology},
  year={2011},
  volume={39 1},
  pages={
          95-101
        }
}
OBJECTIVE Suppression of normal hematopoiesis by the neoplastic clone (clonal dominance) is a feature of the myeloproliferative neoplasms, but the determinants that predict clonal dominance are unknown. The objective of this study was to identify clinical and laboratory variables that associate with the JAK2 V617F CD34(+) progenitor allele burden and clonal dominance, which was defined by congruence of the JAK2 V617F CD34(+) progenitor and neutrophil allele burdens. MATERIALS AND METHODS A… CONTINUE READING
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