Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation.

@article{Ross1985DiseaseassociatedLO,
  title={Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation.},
  author={Gordon D. Ross and William J. Yount and Mark J. Walport and John B. Winfield and Charles F. Parker and C Randall Fuller and Ronald P Taylor and Barry L. Myones and Peter J. Lachmann},
  journal={Journal of immunology},
  year={1985},
  volume={135 3},
  pages={2005-14}
}
Although surface membrane density of complement receptor type one (CR1) on erythrocytes (E) is probably an inherited trait among normal individuals, recent evidence from our laboratories suggests that the reduced number of CR1 per E observed in patients with systemic lupus erythematosus (SLE) results from acquired as well as genetic factors. In the present investigation, the number of CR1 per E was quantitated with 125I-monoclonal anti-CR1 and was found to vary inversely with disease activity… CONTINUE READING
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