Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.

@article{Regal2013DiseaseassociatedMM,
  title={Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.},
  author={Joshua A. Regal and Todd A Festerling and Jeffrey M Buis and David O. Ferguson},
  journal={Human molecular genetics},
  year={2013},
  volume={22 25},
  pages={5146-59}
}
DNA double-strand breaks (DSBs) can lead to instability of the genome if not repaired correctly. The MRE11/RAD50/NBS1 (MRN) complex binds DSBs and initiates damage-induced signaling cascades via activation of the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia- and rad3-related (ATR) kinases. Mutations throughout MRE11 cause ataxia-telangiectasia-like disorder (ATLD) featuring cerebellar degeneration, and cancer-predisposition in certain kindreds. Here, we have examined the impact… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
14 Citations
69 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Similar Papers

Loading similar papers…