Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders

@inproceedings{Tang2011DiseaseAA,
  title={Disease- and age-related changes in histone acetylation at gene promoters in
psychiatric disorders},
  author={Bin Tang and Brian Dean and Elizabeth Anne Thomas},
  booktitle={Translational Psychiatry},
  year={2011}
}
Increasing evidence suggests that epigenetic factors have critical roles in gene regulation in neuropsychiatric disorders and in aging, both of which are typically associated with a wide range of gene expression abnormalities. Here, we have used chromatin immunoprecipitation-qPCR to measure levels of acetylated histone H3 at lysines 9/14 (ac-H3K9K14), two epigenetic marks associated with transcriptionally active chromatin, at the promoter regions of eight schizophrenia-related genes in n=82… CONTINUE READING
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