Disease activity in multiple sclerosis correlates with T lymphocyte expression of the inhibitor of apoptosis proteins.

@article{Semra2002DiseaseAI,
  title={Disease activity in multiple sclerosis correlates with T lymphocyte expression of the inhibitor of apoptosis proteins.},
  author={Yemane K Semra and Osheik A Seidi and Moad K Sharief},
  journal={Journal of neuroimmunology},
  year={2002},
  volume={122 1-2},
  pages={159-66}
}
The pathogenesis of multiple sclerosis (MS) is thought to involve failure of programmed cell death (apoptosis) to eliminate potentially pathogenic, autoreactive T lymphocytes. This failure may be caused by multiple abnormalities of the cell death machinery. The inhibitors of apoptosis (IAP) proteins are central regulators of cell death that inhibit apoptosis induced by a variety of stimuli. In this study, we investigated the dynamics of cellular IAP-1, IAP-2, and X-linked IAP, in resting and… CONTINUE READING

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