Disease Versus Disease: How One Disease May Ameliorate Another

@article{Stiehm2006DiseaseVD,
  title={Disease Versus Disease: How One Disease May Ameliorate Another},
  author={E. Richard Stiehm},
  journal={Pediatrics},
  year={2006},
  volume={117},
  pages={184 - 191}
}
  • E. R. Stiehm
  • Published 1 January 2006
  • Medicine, Biology
  • Pediatrics
Systemic disease, either genetic or acquired, may prevent or decrease the severity of another disease. These observations have led to important therapeutic advances. The best-known examples are Edward Jenner's use in 1798 of cowpox to prevent smallpox and J.B. Haldane's 1942 observation that erythrocyte disorders such as thalassemia and sickle cell disease modify the severity of malaria. Patients with and carriers of cystic fibrosis may have genetic resistance to tuberculosis and/or secretory… 
View on AAP
ncbi.nlm.nih.gov
21 Citations
Highly Influential Citations
1
Background Citations
6

Tables from this paper

21 Citations

Goats, germs, and fever: Are the pyrin mutations responsible for familial Mediterranean fever protective against Brucellosis?

  • J. Ross
  • Biology
    Medical hypotheses
  • 2007

Molecular Genetics of Familial Mediterranean Fever

The high carriage rate of MEFV mutations in classically affected populations may be explained by a potential selection for the heterozygote genotype, which may have conferred some sort of selective advantage for populations in the area but currently there is no proof for this.

Multidrug-Resistant Tuberculosis in an Adult with Cystic Fibrosis

Although nontuberculous mycobacteria are more common in CF, the possibility of TBC should not be ignored and early suspicion of infection due to resistant M. tuberculosis can be life saving.

The mystery of the mystery of common genetic diseases

The mystery of why two particularly extensively studied common genetic diseases, Tay Sachs disease and cystic fibrosis, remain evolutionary mysteries despite decades of research is explained.

Low Prevalence of Selective IgA Deficiency in Infected Children Born to HIV-Seropositive Mothers: An In Vivo Model for Speculation on Selective IgA Deficiency Pathogenesis

IgA serum levels were evaluated in a large cohort of children born to HIV-infected mothers from 1985 to 2006 and it is speculated that several immunological alterations, occurring simultaneously in perinatal HIV infection, surpass the functional defect exhibited in some children with selective IgA deficiency.

Arab gene geography: From population diversities to personalized medical genomics

An overview of Arab gene geography, and various genetic abnormalities in Arab populations, including disorders of blood, metabolic, circulatory and neoplasm, are provided, and their associated molecules or genes responsible for the cause of these disorders are discussed.

The importance of multiparasitism: examining the consequences of co-infections for human and animal health

The goal of this review is to summarise current knowledge on the causes and consequences of multiparasitism and to discuss the different methods and tools that researchers have developed to study the factors that lead to multiparAsitism.

A population genetics study of the Familial Mediterranean Fever gene: evidence of balancing selection under an overdominance regime

The sequence variation and haplotype structure of the MEFV 3′ gene region (from exon 5 to the 3′ UTR) in seven human populations is characterized and evidence for an adaptive role of nucleotide variation in this gene region is provided.

Double-edged genetic swords and immunity: lesson from CCR5 and beyond.

This work is supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, a MERIT award from the National Institutes of Health, and Burroughs Wellcome Clinical Scientist Award in Translational Research.

Genetic analysis of Rwandan patients with cystic fibrosis-like symptoms: identification of novel cystic fibrosis transmembrane conductance regulator and epithelial sodium channel gene variants.

The data suggest that CF-like syndrome in Africa could be associated with CFTR and ENaC mutations, which are not found in the control group.

References

SHOWING 1-10 OF 104 REFERENCES

Coeliac disease

The Marsh classification of intestinal coeliac lesions, as modified by Oberhuber et al, is used by most pathologists to evaluate the intestinal lesions of patients with CD, both for diagnosis and to assess the regression of the lesions after a gluten free diet.

X-Linked Agammaglobulinemia Patients Are Not Infected with Epstein-Barr Virus: Implications for the Biology of the Virus

Investigation of individuals who lack mature B lymphocytes due to the rare heritable disorder X-linked agammaglobulinemia found that none of these individuals harbored EBV in their blood or throat washings, and no EBV-specific memory cytotoxic T lymphocytes were found, suggesting that they had not undergone infection in the past.

The role of red blood cell polymorphisms in resistance and susceptibility to malaria.

  • B. LellJ. May P. Kremsner
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1999
The severity of malaria is partly determined by the presence of blood group A and the sickle cell trait and the different presentation of reinfections in severe versus mild cases probably reflects different susceptibility to malaria.

Histopathological and immunological studies in spontaneous remission of nephrotic syndrome after intercurrent measles infection.

Two cases of childhood nephrotic syndrom (NS) were diagnosed in September 1981 and February 1982, respectively. The patients were first cousins. There was no other family history of renal disease.…

Effect of measles on the nephrotic syndrome.

The effects of intercurrent infections on the nephrotic syndrome are well known and frequently mentioned in the literature, and the occasional published reports of such incidences are usually received with a degree of skepticism.

Thalassaemia and malaria, revisited.

  • D. Weatherall
  • Medicine
    Annals of tropical medicine and parasitology
  • 1997
Recent work indicates that alpha thalassaemia provides protection against severe malaria, and quite unexpectedly at least some of this protection may be mediated by rendering very young children more susceptible to both P. vivax and P. falciparum malaria; such early immunization may provide some protection against the disease in later life.

Isolation of rapidly growing mycobacteria in patients with cystic fibrosis.

THE RARE COEXISTENCE OF LEPROSY AND PSORIASIS

In this article, the findings clearly demonstrate the rare coexistence of the two diseases; although a few cases of psoriasis and leprosy have been previously documented in the Indian medical literature.

Malaria and red cell genetic defects.

Application of DNA analysis and recombinant technology may have an increasing impact on study of the interaction of RBC defects with malarial parasites.

Effect of GB virus C/hepatitis G virus coinfection on the course of HIV infection in hemophilia patients in Japan.

In Japanese hemophilia patients, coinfection with GBV-C/HGV does not have an adverse effect on the course of HIV infection, and progression to AIDS and to death were slower in patients with GBv-C-HGV coinfections than patients without it, although the differences were not statistically significant.
...