Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy

@inproceedings{Chevillard2018DiseaseTA,
  title={Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy},
  author={Christophe Chevillard and Jo{\~a}o Paulo Silva Nunes and Amanda Farage Frade and Rafael Augusto Ribeiro Almeida and Ramendra Pati Pandey and Marilda Sav{\'o}ia Nascimento and Jorge Kalil and Edecio Cunha-Neto},
  booktitle={Front. Immunol.},
  year={2018}
}
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi and affects over 8 million people worldwide. In spite of a powerful innate and adaptive immune response in acute infection, the parasite evades eradication, leading to a chronic persistent infection with low parasitism. Chronically infected subjects display differential patterns of disease progression. While 30% develop chronic Chagas disease cardiomyopathy (CCC)-a severe inflammatory dilated cardiomyopathy-decades after… CONTINUE READING

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 149 REFERENCES

Mannose-binding lectin and Toll-like receptor polymorphisms and Chagas disease in Chile.

  • The American journal of tropical medicine and hygiene
  • 2012
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL