Disease-Specific Induced Pluripotent Stem Cells

  title={Disease-Specific Induced Pluripotent Stem Cells},
  author={In-Hyun Park and Natasha Arora and Hongguang Huo and Nimet Maherali and Tim Ahfeldt and Akiko Shimamura and M. William Lensch and Chad Lin Edith Cowan and Konrad Hochedlinger and George Q. Daley},
Tissue culture of immortal cell strains from diseased patients is an invaluable resource for medical research but is largely limited to tumor cell lines or transformed derivatives of native tissues. Here we describe the generation of induced pluripotent stem (iPS) cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance; these diseases include adenosine deaminase deficiency-related severe combined immunodeficiency (ADA-SCID), Shwachman-Bodian-Diamond… CONTINUE READING
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