Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS

  title={Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS},
  author={Anna Wuolikainen and Thomas Moritz and Stefan L Marklund and Henrik Antti and Peter Munch Andersen},
  booktitle={PloS one},
BACKGROUND/AIM The changes in the cerebrospinal fluid (CSF) metabolome associated with the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) are poorly understood and earlier smaller studies have shown conflicting results. The metabolomic methodology is suitable for screening large cohorts of samples. Global metabolomics can be used for detecting changes of metabolite concentrations in samples of fluids such as CSF. METHODOLOGY Using gas chromatography coupled to mass… CONTINUE READING
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