Disease Flare with Gonadotrophin-Releasing Hormone (GnRH) Analogues

@article{Scaletscky1993DiseaseFW,
  title={Disease Flare with Gonadotrophin-Releasing Hormone (GnRH) Analogues},
  author={R Scaletscky and J Smith},
  journal={Drug Safety},
  year={1993},
  volume={8},
  pages={265-270}
}
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5 Citations
Background Citations
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5 Citations

Advanced delivery of leuprorelin acetate for the treatment of prostatic cancer
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Overall, collected data suggest that the LA gel depot can represent the ADT reference therapy in advanced PCa and results of the registration studies and post-marketing clinical trials demonstrate that theLA gel depot provides long-term efficacy in the clinical practice and a good degree of tolerability.
Effectiveness of cyproterone acetate in achieving castration and preventing luteinizing hormone releasing hormone analogue induced testosterone surge in patients with prostate cancer.
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Two weeks of priming with CPA does not eliminate the surge in serum testosterone (testosterone flare) upon LHRHA administration but the testosterone increase does not exceed pretreatment levels and 2 weeks of CPA may not offer a benefit over 1 week in lowering serum testosterone.
A subcutaneous delivery system for the extended release of leuprolide acetate for the treatment of prostate cancer
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The literature supporting early, adjuvant LHRH therapy and Eligard® 7.5 mg, a new depot formulation of leuprolide acetate that uses the Atrigel® drug delivery system, causing an increase in bioavailability and optimising testosterone suppression are focused on.
A clinical study of 22.5 mg. La-2550: A new subcutaneous depot delivery system for leuprolide acetate for the treatment of prostate cancer.
Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders.
TLDR
Clinical trials in men with advanced prostatic cancer demonstrate that leuprorelin (usually monthly depot injections of 3.75 or 7.5 mg) is less likely to cause serious adverse cardiovascular effects than diethylstilbestrol, and has comparable efficacy to bilateral orchiectomy or other GnRH analogues.

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TLDR
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