Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice.

@article{Wiebelhaus2012DiscriminativeSP,
  title={Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice.},
  author={Jason M. Wiebelhaus and Sarah A. Vunck and Herbert Y Meltzer and Joseph H. Porter},
  journal={Behavioural pharmacology},
  year={2012},
  volume={23 3},
  pages={
          262-70
        }
}
N-desmethylclozapine (NDMC) is the major active metabolite of the atypical antipsychotic drug clozapine and may contribute to the therapeutic efficacy of clozapine. Although they share many pharmacological features, it is noteworthy that NDMC is a partial dopamine D2 and cholinergic muscarinic M1/M4 agonist, whereas clozapine is a weak dopamine D2 receptor inverse agonist/antagonist and a nonselective muscarinic antagonist. To better understand the in-vivo pharmacological mechanisms of these… CONTINUE READING
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