Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist
@article{Minnema2004DiscriminativeSP, title={Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist}, author={D. Minnema and J. S. Hendry and J. Rosecrans}, journal={Psychopharmacology}, year={2004}, volume={83}, pages={200-204} }
Rats were trained to discriminate the putative serotonin (5-HT) antagonist, pizotifen maleate (BC105), from saline using a two-lever drug discrimination paradigm. Pizotifen maleate (6 mg/kg, 14.6 μmol/kg, IP) or saline was administered 55 min prior to the operant training session. The pizotifen discriminative stimulus (DS) had a rapid onset (less than 7 min) and was of long duration. The pizotifen DS was dose dependent. The pizotifen DS did not generalize to the putative 5-HT antagonists… CONTINUE READING
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References
SHOWING 1-10 OF 46 REFERENCES
Discriminative stimulus properties of quipazine: Direct serotonergic mediation
- Psychology, Medicine
- Neuropharmacology
- 1979
- 46
Discriminative stimulus properties of l-5-hydroxytryptophan: Behavioral evidence for multiple serotonin receptors
- Psychology, Medicine
- Psychopharmacology
- 2004
- 12
The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM): Differentiation from amphetamine
- Chemistry, Medicine
- Psychopharmacology
- 2004
- 20
Role of serotonin in the discriminative stimulus properties of mescaline
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1975
- 50
The discriminative stimulus properties of LSD: Mechanisms of action
- Chemistry, Medicine
- Neuropharmacology
- 1978
- 66
The role of dopamine and serotonin in the discriminative stimulus effects of lisuride.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1982
- 28
In vivo evidence of partial agonist activity exerted by purported 5-hydroxytryptamine antagonists.
- Chemistry, Medicine
- European journal of pharmacology
- 1979
- 32
Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD.
- Chemistry, Medicine
- Life sciences
- 1982
- 21