Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist

  title={Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist},
  author={D. Minnema and J. S. Hendry and J. Rosecrans},
  • D. Minnema, J. S. Hendry, J. Rosecrans
  • Published 2004
  • Chemistry, Medicine
  • Psychopharmacology
  • Rats were trained to discriminate the putative serotonin (5-HT) antagonist, pizotifen maleate (BC105), from saline using a two-lever drug discrimination paradigm. Pizotifen maleate (6 mg/kg, 14.6 μmol/kg, IP) or saline was administered 55 min prior to the operant training session. The pizotifen discriminative stimulus (DS) had a rapid onset (less than 7 min) and was of long duration. The pizotifen DS was dose dependent. The pizotifen DS did not generalize to the putative 5-HT antagonists… CONTINUE READING
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