Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor

@article{Pratt1983DiscriminativeSP,
  title={Discriminative stimulus properties of nicotine: Further evidence for mediation at a cholinergic receptor},
  author={Judith A. Pratt and Ian P. Stolerman and Harbakhsh S. Garcha and Valerio Giardini and Colin Feyerabend},
  journal={Psychopharmacology},
  year={1983},
  volume={81},
  pages={54-60}
}
Rats were trained to discriminate nicotine (0.4 mg/kg SC) from saline in a standard two-bar operant conditioning procedure with food reinforcement. The response to nicotine was dose-related and at the ED50 of 0.14 mg/kg, plasma nicotine concentrations were similar to those reported previously for cigarette smokers who inhale. The nicotine analogues anabasine and cytisine increased nicotine-appropriate responding in a dose-related manner. Animals predominantly responded on the saline-associated… CONTINUE READING
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Anabasine and cytisine : nicotinelike behavioural effects in a drugdiscrimination procedure

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  • 1983

Further analysis

  • IP Stolerman, JA Pratt, HS Garcha
  • 1982
1 Excerpt

Further analysis of the nicotine cue in rats

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  • 1982

Non - cholinergic , saturable binding of ~ )[ 3 H ] nieotine to mouse brain

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