Discriminative stimulus properties of fentanyl and morphine: Tolerance and dependence

@article{Colpaert1976DiscriminativeSP,
  title={Discriminative stimulus properties of fentanyl and morphine: Tolerance and dependence},
  author={F. C. Colpaert and J J Kuyps and Carlos J. E. Niemegeers and Paul Adriaan Jan Janssen},
  journal={Pharmacology Biochemistry and Behavior},
  year={1976},
  volume={5},
  pages={401-408}
}
Using a food-reinforced two-lever operant procedure, rats were trained to discriminate 0.04 mg/kg fentanyl from saline. At different time intervals after the establishment of discriminative responding, stimulus generalization experiments were performed with equivalent dose ranges of fentanyl (0.0025 to 0.02 mg/kg) and morphine (2.5 to 20 mg/kg). It was found that the ED50 values of both compounds for generalization with the narcotic discriminative stimulus complex, did not change over a 4-month… CONTINUE READING
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Modification of the morphine withdrawal syndrome in rats

  • A. P. Fertziger
  • Psychopharmacologia
  • 1976

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