• Corpus ID: 42624984

Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats.

@article{Imaizumi1994DiscriminativeSP,
  title={Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats.},
  author={Masahiro Imaizumi and Shuichi Miyazaki and Haruhiko Machida},
  journal={Arzneimittel-Forschung},
  year={1994},
  volume={44 10},
  pages={
          1105-7
        }
}
A stimulus cue of 1-amino-5-bromouracil (ABU, CAS 127984-93-4) was compared with that of diazepam (DZP) using a drug discrimination paradigm in rats. Groups of rats were trained to discriminate DZP (1 mg/kg i.p.) or ABU (20 mg/kg i.p.) from vehicle. Generalization of the cue of the trained drug to pentobarbital was shown in DZP- and ABU-trained rats at a dose of 5 mg/kg. The stimulus cue of ABU showed a tendency to generalize to DZP in ABU-trained rats but generalization of that of DZP to ABU… 
Effect of 1-amino-5-bromouracil on brain monoamine metabolism in rats
TLDR
Results indicate that these two physiologic stresses affected monoaminergic neurons differently and that their effects were suppressed by ABU and diazepam.
Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex.
TLDR
In vivo studies suggest that part of the central action of 1-amino-5-bromouracil is concerned with the benzodiazepine-GABAA receptor complex including the chloride channel.
Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors
TLDR
In mice made prediabetic via diet-induced obesity, IND was no longer effective in increasing long-term object memory recognition nor increasing anxiolytic behavior, suggesting state dependency or a degree of insulin resistance related to these behaviors.
AwakeIntranasalInsulinDeliveryModifiesProtein ComplexesandAltersMemory,Anxiety,andOlfactory Behaviors
The role of insulin pathways in olfaction is of significant interest with the widespread pathology of diabetes mellitus and its associated metabolic and neuronal comorbidities. The insulin receptor