Discriminative stimulus properties of phenylisopropylamine derivatives.

  title={Discriminative stimulus properties of phenylisopropylamine derivatives.},
  author={Richard A Glennon},
  journal={Drug and alcohol dependence},
  volume={17 2-3},
The phenylisopropylamine unit is a common structural fragment amongst many centrally-acting agents. However, these agents do not necessarily produce similar behavioral effects in test subjects. For example, the phenylisopropylamine derivative amphetamine is a central nervous system (CNS) stimulant whereas its 2,5-dimethoxy-4-methyl analog, i.e. DOM, is considered to be a hallucinogen. Employing animals trained to discriminate either (+)-amphetamine or (+/-)-DOM from saline in a two-lever… CONTINUE READING

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