Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studies

@article{Porter2008DiscriminativeSP,
  title={Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studies},
  author={Joseph H. Porter and Adam J Prus},
  journal={Psychopharmacology},
  year={2008},
  volume={203},
  pages={279-294}
}
Drug discrimination is an increasingly valuable behavioral assay for the preclinical development of antipsychotic drugs. The majority of studies have used the atypical antipsychotic clozapine because it displays robust discriminative stimulus properties and is the “prototypical” or “gold standard” atypical antipsychotic against which other antipsychotics will undoubtedly be compared for many years. Pharmacological mechanisms mediating the discriminative stimulus properties of antipsychotics… CONTINUE READING
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