Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites.

@article{Holtzman1979DiscriminativeSP,
  title={Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites.},
  author={Stephen G. Holtzman},
  journal={Pharmacology, biochemistry, and behavior},
  year={1979},
  volume={10 4},
  pages={
          565-8
        }
}
The discriminative stimulus properties of l-alpha-acetylmethadol (LAAM), its metabolities 1-alpha-acetyl-N-normethadol (NorLaam) and l-alpha-acetyl-N,N-dinormethadol (DiNorLAAM), and methadone were evaluated in rats trained to discriminate between saline and morphine in a two-choice discrete-trial avoidance paradigm. All four compounds produced dose-related increases in the number of trials completed on the morphine-appropriate choice lever after either SC or oral administration indicating that… CONTINUE READING