Discriminative stimulus properties of pentylenetetrazol and bemegride: Some generalization and antagonism tests

@article{Shearman1979DiscriminativeSP,
  title={Discriminative stimulus properties of pentylenetetrazol and bemegride: Some generalization and antagonism tests},
  author={Gary Terence Shearman and Harbans Lal},
  journal={Psychopharmacology},
  year={1979},
  volume={64},
  pages={315-319}
}
In an operant procedure of lever pressing on a FR 10 schedule of food reinforcement, male hooded rats were trained to respond with a lever on one side of a food cup following a drug injection, and to respond with a lever on the alternate side following a 1ml/kg saline injection. All of 14 subjects learned to discriminate reliably between the effects of 20 mg/kg pentylene-tetrazol (PTZ) and saline. Seven of eight rats learned to discriminate between the effects of bemegride (5 mg/kg) and saline… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Neuropharmacology of the interoceptive stimulus properties of nicotine.

  • Current drug abuse reviews
  • 2009
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawal.

  • The Journal of pharmacology and experimental therapeutics
  • 1999
VIEW 6 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Discriminative stimulus ( DS ) properties of picrotoxin , bemegride and pentylenetetrazol ( PTZ ) : A possible relationship between an anxiogenic action and PTZDS

F. C. Colpaert, J. A. Rosecrans, G. Shearman, H. Lal
  • Fed . Proc .
  • 1979

Discriminative stimulus ( DS ) properties of picrotoxin , bemegride and pentylenetetrazol ( PTZ ) : A possible relationship between an anxiogenic action and PTZDS

F. C. Colpaert, J. A. Rosecrans, G. Shearman, H. Lal
  • Fed . Proc .
  • 1979

Preclinical neuropsychopharmacological procedures for axiolytic drugs

A. S. Lippa, P. A. Nash, E. N. Greenblatt
  • 1979

Preclinical neuropsychopharmacological procedures for axiolytic drugs

A. S. Lippa, P. A. Nash, E. N. Greenblatt
  • 1979

Discriminative Stimulus Properties of Drugs

  • Advances in Behavioral Biology
  • 1977
VIEW 2 EXCERPTS

Quantitative structure activity relationship in minor tranquilizers . Benzodiazepineixazole derivatives

M. Yoshimoto, T. Kamioka, +3 authors R. Tachikawa
  • Chem . Pharm . Bull . ( Tokyo )
  • 1977