Discriminative stimulus properties of l-5-hydroxytryptophan: Behavioral evidence for multiple serotonin receptors

@article{Barrett2004DiscriminativeSP,
  title={Discriminative stimulus properties of l-5-hydroxytryptophan: Behavioral evidence for multiple serotonin receptors},
  author={R. Barrett and M. A. Blackshear and E. sanders-Bush},
  journal={Psychopharmacology},
  year={2004},
  volume={76},
  pages={29-35}
}
  • R. Barrett, M. A. Blackshear, E. sanders-Bush
  • Published 2004
  • Psychology, Medicine
  • Psychopharmacology
  • Rats were trained to discriminate the stimulus properties of l-5-hydroxytryptophan (l-5-HTP) (30 mg/kg SC), the immediate precursor of serotonin (5-HT). The peripheral decarboxylase inhibitor R04-4602, administered prior to l-5-HTP, greatly attenuated the disruptive effects observed on responding when l-5-HTP alone was injected. Following acquisition, the discrimination was dosedependent and generalized to fenfluramine, a 5-HT-releasing drug, but not to amphetamine, a catecholamine-releasing… CONTINUE READING
    12 Citations
    Additional evidence that l-5-hydroxytryptophan discrimination models a unique serotonin receptor
    • 8
    Discriminative stimulus properties of the serotonin agonist MK 212
    • 20
    Drugs affecting serotonin neurons.
    • R. Fuller
    • Biology, Medicine
    • Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
    • 1990
    • 8
    Role of tryptophan in the pathogenesis of hepatic encephalopathy.
    • 16
    • PDF
    Drug Discrimination Learning
    • 10

    References

    SHOWING 1-10 OF 46 REFERENCES
    Discriminative stimulus properties of quipazine: Direct serotonergic mediation
    • 46
    Role of peripheral mechanisms in the behavioral effects of 5-hydroxytryptophan
    • 31
    Role of serotonin in the discriminative stimulus properties of mescaline
    • 50
    Hallucinogens as a discriminative stimuli: generalization of DOM to a 5-methoxy-N, N-dimethyltryptamine stimulus.
    • 33
    Pre- and postsynaptic serotonergic manipulations in an animal model of depression
    • 92
    Specificity of a rat behavioral model for serotonin receptor activation.
    • 139
    Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramine.
    • 258
    The discriminative stimulus properties of LSD: Mechanisms of action
    • 66