Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.

@article{France1984DiscriminativeSE,
  title={Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine.},
  author={C P France and Arthur E. Jacobson and J. H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={230 3},
  pages={652-7}
}
Pigeons were trained under a multiple-trial procedure to discriminate morphine (5.6 mg/kg) from saline. Morphine, oxymorphazone and buprenorphine each occasioned complete drug-appropriate responding in a dose-related manner and, at larger doses, suppressed responding completely. The order of potency as discriminative stimuli was buprenorphine greater than oxymorphazone greater than morphine; the potencies in suppressing responding were oxymorphazone greater than morphine greater than… CONTINUE READING

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