Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds.

Abstract

Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam, and dopamine D2-like receptor antagonists, all of which have been… (More)

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