Discriminative stimulus effects of ethanol: neuropharmacological characterization.

@article{Kostowski1999DiscriminativeSE,
  title={Discriminative stimulus effects of ethanol: neuropharmacological characterization.},
  author={Wojciech Kostowski and P. Bieńkowski},
  journal={Alcohol},
  year={1999},
  volume={17 1},
  pages={
          63-80
        }
}
Generally, compounds discriminated by animals possess psychotropic effects in animals and humans. As with many other drugs of abuse, strength of the ethanol discriminative stimulus is dose related. The majority of studies show that doses close to 1.0 g/kg are close to the minimum at which the discrimination can be learned easily. Substitution studies suggest that anxiolytic, sedative, atactic, and myorelaxant effects of ethanol all play an important role in the formation of its intercoeptive… Expand
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Pharmacological and Anatomical Evidence for an Interaction Between mGluR5- and GABAA α1-Containing Receptors in the Discriminative Stimulus Effects of Ethanol
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TLDR
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Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.
It has been repeatedly reported that NMDA receptors may contribute to ethanol-induced discriminative stimulus effects and withdrawal syndrome. However, the role of NMDA receptors in the reinforcingExpand
Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat.
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Results may indicate that 5-HT neurons of the DRN are not critically involved in ethanol discrimination in the rat, as they did not differ between the groups. Expand
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TLDR
There are no major differences between full and partial, nonselective BZ receptor agonists in their ability to substitute for 1.0 g/kg dose of ethanol, and stimulation of BZ1 receptors alone is not sufficient to produce ethanol-like discriminative stimulus effects in the rat. Expand
Discriminative stimulus effects of ethanol: lack of antagonism with N-methyl-D-aspartate and D-cycloserine.
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Results indicate that at least certain agonists at the NMDA receptor complex do not attenuate the ethanol interoceptive cue in the rat. Expand
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The limited ethanol-like effects of zolpidem, zaleplon and SX 3228 may be related to the more selective mechanism of action of these compounds, which are reported to have selectivity for the BZ1 (ω1) receptor subtype. Expand
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TLDR
This study strongly suggests that the discriminative stimulus properties of ethanol are not mediated through an agonist action on adenosine-receptive neurons. Expand
Discriminative stimulus properties of ethanol in the rat: effects of neurosteroids and picrotoxin 1 Part of these data was presented on ′5. Tagung des Arbeitskreises Neuropharmacologie und -toxicologie′, 13–14 September 1996, Magdeburg, Germany. 1
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TLDR
The results suggest that the pharmacological effects of ethanol, which can control behavior, may seemingly be modified by training conditions, to the extent that a receptor system prominently linked to the behavioral activity of ethanol (i.e. GABAA) appears no longer to be involved in the interoceptive effects of the drug. Expand
Drug discrimination analysis of ethanol as an N-methyl-D-aspartate receptor antagonist.
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The effects of ethanol on NMDA discrimination are distinct from those previously reported for competitive NMDA antagonists but similar to those of noncompetitive antagonists. Expand
Discriminative stimulus function of ethanol: role of GABAA receptors in the nucleus accumbens.
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TLDR
The data suggest that ethanol discrimination is mediated centrally and demonstrate that infusions of the GABAA agonist muscimol in the N Acc are sufficient to produce the stimulus effects corresponding to a 1.0 g/kg training dose of ethanol. Expand
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It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the presentExpand
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