Discriminative stimulus effects of centrally administered isoproterenol in rats: mediation by beta-1 adrenergic receptors

@article{Crissman2000DiscriminativeSE,
  title={Discriminative stimulus effects of centrally administered isoproterenol in rats: mediation by beta-1 adrenergic receptors},
  author={Alicia M. Crissman and Malath M. Makhay and James M. O'Donnell},
  journal={Psychopharmacology},
  year={2000},
  volume={154},
  pages={70-75}
}
Rationale: Centrally active beta-1 and beta-2 adrenergic agonists produce antidepressant-like effects in several behavioral tests, suggesting that these receptors may be involved in the mediation of the effects of antidepressant drugs. Objectives: This study aimed to evaluate the ability of intra-cerebral ventricular (ICV) isoproterenol to produce discriminative stimulus effects mediated by beta adrenergic receptors, establishing a reliable model of in vivo activation of central beta adrenergic… CONTINUE READING
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