Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression.

@article{Nesnow2009DiscriminationOT,
  title={Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression.},
  author={Stephen Nesnow and William Ward and T. H. M. Moore and Hongzu Ren and Susan D. Hester},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={110 1},
  pages={68-83}
}
Conazoles are fungicides used to control fungal growth in environmental settings and to treat humans with fungal infections. Mouse hepatotumorigenic conazoles display many of the same hepatic toxicologic responses as the mouse liver carcinogen phenobarbital (PB): constitutive androstane receptor (CAR) activation, hypertrophy, Cyp2b induction, and increased cell proliferation. The goal of this study was to apply transcriptional analyses to hepatic tissues from mice exposed to PB, propiconazole… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 56 references

Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.

Toxicological sciences : an official journal of the Society of Toxicology • 2007
View 14 Excerpts
Highly Influenced

Phenobarbital and its sodium salt

IARC.
IARC Monographs, Some Thyrotropic Agents, pp. 161–288. IARC Press, Lyon, France. • 2001
View 4 Excerpts
Highly Influenced

Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.

Drug metabolism and disposition: the biological fate of chemicals • 2003
View 7 Excerpts
Highly Influenced

Monograph 768

INCHEM.
Propiconazole part II toxicology. In Pesticide Residues in Food: 1987 Evaluations, p. 19. Available at: http:// www.inchem.org/documents/jmpr/jmpmono/v87pr13.htm. Accessed April 27, 2009. • 1987
View 4 Excerpts
Highly Influenced

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