Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing.

@article{Both2014DiscriminationOE,
  title={Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing.},
  author={Peter Both and Anthony P Green and Christopher J. Gray and R{\'o}bert Sardz{\'i}k and Josef Voglmeir and Carolina Fontana and M Austeri and Martin Rejzek and Douglas Richardson and Robert A Field and Goeran Widmalm and S L Flitsch and Claire E Eyers},
  journal={Nature chemistry},
  year={2014},
  volume={6 1},
  pages={65-74}
}
Mass spectrometry is the primary analytical technique used to characterize the complex oligosaccharides that decorate cell surfaces. Monosaccharide building blocks are often simple epimers, which when combined produce diastereomeric glycoconjugates indistinguishable by mass spectrometry. Structure elucidation frequently relies on assumptions that biosynthetic pathways are highly conserved. Here, we show that biosynthetic enzymes can display unexpected promiscuity, with human glycosyltransferase… CONTINUE READING
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