Discrimination of epidemic and nonepidemic methicillin-resistant Staphylococcus aureus strains on the basis of protein A gene polymorphism.

@article{Frenay1994DiscriminationOE,
  title={Discrimination of epidemic and nonepidemic methicillin-resistant Staphylococcus aureus strains on the basis of protein A gene polymorphism.},
  author={Hendrina M.E. Frenay and J P Theelen and Leo M. Schouls and Christina M. J. E. Vandenbroucke-Grauls and J. C. Barendrecht Verhoef and Wibeke J van Leeuwen and Frits R. Mooi},
  journal={Journal of clinical microbiology},
  year={1994},
  volume={32 3},
  pages={846-7}
}
The X region of the protein A gene of Staphylococcus aureus contains a highly polymorphic sequence which is composed of repeats of 24 bp. We used amplification by PCR to investigate whether this region could be used to discriminate between epidemic and nonepidemic methicillin-resistant S. aureus (MRSA) strains. Most epidemic MRSA strains (24 of 33) harbored more than seven repeats, while most nonepidemic MRSA strains (10 of 14) contained seven or fewer repeats. It is conceivable that a longer X… CONTINUE READING