Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2.

@article{Castrillon2001DiscriminationOC,
  title={Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2.},
  author={Diego H. Castrillon and Deqin Sun and Stanislawa Weremowicz and R. A. Fisher and Christopher P Crum and David R. Genest},
  journal={The American journal of surgical pathology},
  year={2001},
  volume={25 10},
  pages={1225-30}
}
The p57KIP2 protein is a cell cycle inhibitor and tumor suppressor encoded by a strongly paternally imprinted gene. We explored the utility of p57KIP2 as a diagnostic marker in hydatidiform mole, a disease likely the result of abnormal dosage and consequent misexpression of imprinted genes. Using a monoclonal antibody on paraffin-embedded, formalin-fixed tissue sections, the authors evaluated p57KIP2 expression in normal placenta and in 149 gestations including 59 complete hydatidiform moles… CONTINUE READING

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