Discrimination between drug-resistant and non-resistant human melanoma cell lines by FTIR spectroscopy.

@article{Zwielly2009DiscriminationBD,
  title={Discrimination between drug-resistant and non-resistant human melanoma cell lines by FTIR spectroscopy.},
  author={Amir Zwielly and Jacob Gopas and Gordana Brkic and Shaul Mordechai},
  journal={The Analyst},
  year={2009},
  volume={134 2},
  pages={294-300}
}
We investigated the ability of FTIR-microscopy to define spectral changes between drug-sensitive and drug-resistant human melanoma cells. As a model system, a resistant melanoma cell line (GAC) was selected with cisplatin from parental (GA) cells. Using Fourier transform infrared spectroscopy (FTIR) we investigated the ability to differentiate between the resistant variant derived from the sensitive parental cell line, in the absence of cisplatin. We determined and validated spectral parameters… CONTINUE READING

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