Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc.

@article{Desbarats1996DiscriminationBD,
  title={Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc.},
  author={L Desbarats and Stefan Gaubatz and Martin Eilers},
  journal={Genes & development},
  year={1996},
  volume={10 4},
  pages={447-60}
}
c-myc plans a key role in regulating mammalian cell proliferation and apoptosis. The gene codes for a transcription factor, Myc, that belongs to the helix-loop-helix/leucine zipper (HLH/LZ) family of proteins. Myc heterodimerizes with a partner protein termed Max; the heterodimeric complex binds to CAC(G/A)TG (E-box) sequences and activates transcription from these sites. However, several other HLH/LZ proteins, including USF and TFE-3, bind to and trans-activate from the same element, yet have… CONTINUE READING
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