Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling.

@article{Hu2014DiscriminationB5,
  title={Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling.},
  author={Jianlin Hu and Yuqi Chen and Xiaowei Xu and Fan Wu and Xiwen Xing and Zhenghao Xu and Jiahui Xu and Xiaocheng Weng and Xiang Zhou},
  journal={Bioorganic & medicinal chemistry letters},
  year={2014},
  volume={24 1},
  pages={294-7}
}
Detection of DNA damage has been greatly improved following the development of equipment and techniques, however, discrimination between 5-hydroxymethylcytosine (5-hmC) and 5-methylcytosine (5-mC) is still a thorny problem. In the present study, an approach to oxidize and selective label (Ox-Labeling) 5-hmC in native DNA has been reported, which… CONTINUE READING