Discrimination against deoxyribonucleotide substrates by bacterial RNA polymerase.

  title={Discrimination against deoxyribonucleotide substrates by bacterial RNA polymerase.},
  author={Vladimir Svetlov and Dmitry G. Vassylyev and Irina Artsimovitch},
  journal={The Journal of biological chemistry},
  volume={279 37},
Nucleic acid polymerases have evolved elaborate mechanisms that prevent incorporation of the non-cognate substrates, which are distinguished by both the base and the sugar moieties. While the mechanisms of substrate selection have been studied in single-subunit DNA and RNA polymerases (DNAPs and RNAPs, respectively), the determinants of substrate binding in the multisubunit RNAPs are not yet known. Molecular modeling of Thermus thermophilus RNAP-substrate NTP complex identified a conserved beta… CONTINUE READING

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Substrate Selection by Bacterial RNA Polymerase 38090 at U iv of A labam a B irm inham

  • S. Uptain, C. Kane, M. Chamberlin
  • Annu. Rev. Biochem
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