Discriminating toxicant classes by mode of action. 1. (Eco)toxicity profiles.

  title={Discriminating toxicant classes by mode of action. 1. (Eco)toxicity profiles.},
  author={Monika Nendza and Andrea Wenzel},
  journal={Environmental science and pollution research international},
  volume={13 3},
BACKGROUND AND SCOPE Predictive toxicology, particularly quantitative structure-activity relationships (QSARs), require classification of chemicals by mode of action (MOA). MOA is, however, not a constant property of a compound but it varies between species and may change with concentration and duration of exposure. A battery of MOA-specific in-vitro and low-complexity assays, featuring biomolecular targets for major classes of environmental pollutants, provides characteristic responses for (1… CONTINUE READING


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