Discriminating the effects of Cannabis sativa and Cannabis indica: a web survey of medical cannabis users.

  title={Discriminating the effects of Cannabis sativa and Cannabis indica: a web survey of medical cannabis users.},
  author={Daniel D. Pearce and Katherine Mitsouras and Kristopher J. L. Irizarry},
  journal={Journal of alternative and complementary medicine},
  volume={20 10},
OBJECTIVE To evaluate the opinions of medical cannabis (MC) users on the effects of Cannabis indica vs. those of Cannabis sativa on conditions and symptoms through an online survey. DESIGN Survey of 95 non-randomly assigned MC users. A two-sided chi-square test followed by Bonferroni post hoc multiple comparison and Fisher exact test were used to determine correlations. The Cronbach α was used to determine internal consistency. SETTING Announcements on 13 MC websites with links to… 

The Use of Cannabinoids for Insomnia in Daily Life: Naturalistic Study.

Medicinal cannabis users perceive a significant improvement in insomnia with cannabinoid use, and this study suggests a possible advantage with the use of predominant indica strains compared with predominant sativa strains and exclusively CBD in this population.

The Association between Cannabis Product Characteristics and Symptom Relief

Across product characteristics, only higher THC levels were independently associated with greater symptom relief and prevalence of positive and negative side effects, and in contrast, CBD potency levels were generally not associated with significant symptom changes or experienced side effects.

Pain, Cannabis Species, and Cannabis Use Disorders.

Individuals who use cannabis to manage chronic pain may be at a lower risk for cannabis use problems, relative to individuals who use it for other indications, potentially as a function of their species preference.

Training and Practices of Cannabis Dispensary Staff

Although many dispensary staff are making recommendations consistent with current evidence, some are recommending cannabis that has either not been shown effective for, or could exacerbate, a patient's condition.

Mother of Berries, ACDC, or Chocolope: Examination of the Strains Used by Medical Cannabis Patients in New England

  • B. Piper
  • Medicine
    Journal of psychoactive drugs
  • 2018
Strain preferences were highly state/dispensary specific with one-fifth of MC patients in Maine preferring Mother of Berries and many respondents mentioned that they had developed a time-dependent pattern with sativa use during the day and an indica for nighttime use and for improving sleep.

Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience

Medical cannabis was found to improve symptoms of PD in the initial stages of treatment and did not cause major adverse effects in this pilot, 2-center, retrospective survey.

Values and preferences towards medical cannabis among people living with chronic pain: a mixed-methods systematic review

The variability of patients’ values and preferences emphasise the need for shared decision making when considering medical cannabis for chronic pain and highlight factors that clinicians should consider when discussing medical cannabis.

Cannabis and Its Different Strains.

It is shown that cannabis intake leads to overproductions, suggesting that regular users' internal tempo slows down after acute intoxication, and the relevance of including the type of strain consumed in cannabis studies is highlighted.

Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats

Chronic cannabis smoke exposure in rats leads to clinically relevant Δ9-THC levels, dependence, and has a biphasic effect on locomotor activity.



The medicinal use of cannabis in the UK: results of a nationwide survey

The results of a self‐administered questionnaire study conducted in the United Kingdom between 1998 and 2002 point to the need for clinical studies of cannabis and cannabinoids with standardised and quality‐controlled products.

How important are sex differences in cannabinoid action?

Both clinical and laboratory‐based research evidence revealing important sex‐related differences in cannabinoid effects are reviewed, and some suggestions for future studies are put forward to fill the gap in the knowledge of gender‐specific bias in cannabinoid pharmacology.

Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity of pain, improved sleep and was well tolerated, and no differences in mood or quality of life were found.

A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae).

A two-species concept of Cannabis is supported by the determined frequencies of B(D) and B(T) in sample populations of 157 Cannabis accessions determined from CBD and THC banding patterns, visualized by starch gel electrophoresis.

Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980-1997.

The analysis of 35,312 cannabis preparations confiscated in the USA over a period of 18 years for delta-9-tetrahydrocannabinol (delta9-THC) and other major cannabinoids is reported, showing that the potency of confiscated marijuana samples has continuously risen, going from 3.1% in 1992 to 4.2% in 1997.

Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults

Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.

The neurobiology and evolution of cannabinoid signalling.

  • M. ElphickM. Egertová
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
A model of cannabinoid signalling is presented in which anandamide is synthesized by postsynaptic cells and acts as a retrograde messenger molecule to modulate neurotransmitter release from presynaptic terminals, concluding that the cannabinoid signalling system may be quite restricted in its phylogenetic distribution.