Discriminating in favour of or against men with increased risk of finasteride‐related side effects?

  title={Discriminating in favour of or against men with increased risk of finasteride‐related side effects?},
  author={Ralph M Tr{\"u}eb},
  journal={Experimental Dermatology},
  • R. Trüeb
  • Published 1 June 2017
  • Medicine
  • Experimental Dermatology
Based on observations of Julianne Imperato-McGinley of Cornell Medical College, New York presented at a conference on birth defects in 1974 on a peculiar genetic disorder due to type 2 5α-reductase deficiency (5-ARD), oral finasteride was approved in 1992 by the U.S. Food and Drug Administration for treatment of benign prostatic hyperplasia (BPH), and in 1997 for treatment of male pattern baldness (MPB). 
A Comment on the Post-Finasteride Syndrome
It is as inappropriate to dismiss the condition, as it would be to demonize finasteride for the treatment of male pattern hair loss, while the best way to alleviate the emotional distress related to hair loss is to effectively treat the condition causing the problem.
The postfinasteride syndrome; an overview
It is argued that finasteride adverse effects occurring during Finasteride administration should be delineated from postfinasteride side effects (encountered after treatment cessation), suggesting the need to be addressed separately within a therapeutic perspective.


Are hand preference and sexual orientation possible predicting factors for finasteride adverse effects in male androgenic alopecia?
The preliminary published data and the arguments presented here suggest that these two individual parameters might be used by dermatologists in the therapeutic approach of male androgenic alopecia, so as to alert specific subsets of men, prior to treatment, of the potential increased risk for developing adverse effects to finasteride.
Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.
INTRODUCTION 5α-reductase inhibitors (5α-RIs), finasteride and dutasteride, have been approved for treatment of lower urinary tract symptoms, due to benign prostatic hyperplasia, with marked clinical
Evaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopecia
In Japanese men with AGA, oral finasteride used in the long‐term study maintained progressive hair regrowth without recognized side‐effect.
Persistent sexual side effects of finasteride: could they be permanent?
Comment is that the majority of the study data was based on a small cohort of registered patients on a webpage and no serum hormone levels, especially testosterone or dihydrotestosterone were measured, and it is difficult to calculate incidence of a side effect without knowing the population of all patients who used the prescribed drug.
Psychosexual Characteristics of Men and Women Exposed Prenatally to Diethylstilbestrol
Overall, the findings provide little support for the hypothesis that prenatal exposure to DES influences the psychosexual characteristics of adult men and women.
Psychiatric comorbidity in gender identity disorder.
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