Discriminating gene expression profiles of memory B cell subpopulations

  title={Discriminating gene expression profiles of memory B cell subpopulations},
  author={G{\"o}tz R.A. Ehrhardt and Atsushi Hijikata and Hiroshi Kitamura and Osamu Ohara and J Wang and Max D. Cooper},
  journal={The Journal of Experimental Medicine},
  pages={1807 - 1817}
Morphologically and functionally distinct subpopulations of human memory B (B(Mem)) cells are identifiable by either their expression of CD27 or Fc receptor-like 4 (FCRL4), an immunoglobulin domain containing a receptor with strong inhibitory potential. We have conducted comparative transcriptome and proteome analyses of FCRL4(+) and FCRL4(-) B(Mem) cells and found that these two subsets have very distinctive expression profiles for genes encoding transcription factors, cell-surface proteins… CONTINUE READING


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