Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test.

@article{Dartel2011DiscriminatingCO,
  title={Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test.},
  author={Dorien A.M. van Dartel and Jeroen L. A. Pennings and Joshua F Robinson and Jos Kleinjans and Aldert H. Piersma},
  journal={Toxicology letters},
  year={2011},
  volume={201 2},
  pages={143-51}
}
The embryonic stem cell test (EST) has been shown to be a promising in vitro method for the prediction of developmental toxicity. In our previous studies, we demonstrated that the implementation of gene expression analysis in the EST may further improve the identification of developmental toxicants. In the present study, we investigated if gene expression profiling could be used to discriminate compound classes with distinct modes of action (MoA) using the EST protocol. Gene expression data of… CONTINUE READING

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2010c. Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes

  • D.A.M. van Dartel, J.L.A. Pennings, +4 authors A. H. Piersma
  • Toxicol. Sci
  • 2010
Highly Influential
11 Excerpts

Molecular aspects of azoles-induced teratogenesis

  • F. arotta, G. M. Tiboni
  • Expert Opin. Drug Metab. Toxicol
  • 2010

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